Biofunctionalization of hydrogel-based scaffolds for vascular tissue regeneration

Congenital and acquired tissular losses due to disease or trauma are a major world health problem. Regenerative therapy aims fix damaged tissues by directing the natural capacity of host organism use biofunctionalized artificial tissue scaffolds. These three-dimensional (3D) scaffolds can be customized with cells and/or bioactive molecules induce cellular homing angiogenesis, essential ensure successful regeneration. Hydrogels (HGs) networks hydrophilic homopolymers, copolymers, macromers chemical biological activities that enhance their cell colonization. The HGs in regenerative medicine has shown advantageous since prepared under clinical-grade conditions tailored specific needs replaced tissue. They made emulate native extracellular matrices (ECMs) including physical, mechanical, cues resilience properties. reproduce hygroscopic original which improves anchoring, nutrition, waste disposal. enable molecular modification conducive microenvironment, modifying properties scaffold, improving chemotaxis, adhesion, migration, proliferation, differentiation, angiogenesis; created linked growth factors synthetic peptides positively influence scaffold colonization functional biocompatibility. This review collect most relevant information regarding biofunctionalization used for vascular regeneration, effects, clinical implications. While still investigation, some them have been studied vitro, ex vivo , promising results . In this regard, studies such as chitosan hydrogel LL-37 promotes angiogenesis healing pressure ulcers. Also, GHK tripeptide is widely trials focused on guided remodeling.